What is the Basal Lamina?

Throughout the body a thin membrane surrounds cells
and tissues and has a profound effect on their activity and function. This membrane is called the basal lamina. The basal lamina's effects on tissue function includes the development and preservation of specialized function,
and the response to disease and injury. The basal lamina thus functions as the tissue's "operating system", directing the activity and function of cells and tissues in both health and disease.

Why is the Basal Lamina Important?

The basal lamina is present in virtually all tissues,
and plays a central role in maintaining healthy tissues
and mediating disease processes. If the basal lamina is
not functioning properly, whether due to injury or disease, the tissues of the body are dramatically affected. This fundamental relationship is the cornerstone of BioStratum's search for new therapies for diseases that currently have
no cure. The basal lamina is directly involved in disease processes that are fundamental to chronic and degenerative diseases, such as diabetic complications, cancer and autoimmune disease. Understanding the molecular basis
of this involvement has lead to the identification of novel therapeutic approaches and drug candidates for these important diseases.

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