Laminins are large, complex, extra-cellular matrix molecules that reside
principally in the basal lamina.
These molecules impart a multi-functional influence over cells and tissues,
and directly effect cell behavior and
cell phenotype. This influence is mediated via binding interactions with
cell receptors. Laminins play a critical
role in tissue development and regeneration. Several laboratories have
demonstrated the addition of exogenous laminin to injured tissue promotes
cell attachment, cell proliferation and tissue regeneration. Consequently,
laminins may represent an important new molecular approach for developing
BioStratum and its collaborating scientists have developed advanced recombinant
technology to produce human laminin molecules. This scientific advancement
is the result of a collaboration between BioStratum and some leading scientists
in the laminin and type IV collagen field from
the Robert Wood Johnson Medical School, the Karolinska Institute, and
the University of Kansas Medical Center.
The production of laminin constitutes we believe the
largest and most complex protein molecule ever produced by recombinant
technology. The Company can currently produce three human recombinant
(r-laminin-8, r-laminin-5 and r-laminin-2) that are currently being evaluated
for the treatment of periodontal, vascular, and skin diseases.