The basal lamina of the glomerulus of the kidney is the target of the
autoimmune disease Goodpasture sydrome. BioStratum scientists have determined
the structure of
the autoantigenic site in this disease. A careful analysis
of the structure and function of this autoantigenic site has led to an
understanding of what causes the body's proteins to become autoantigenic.
This research indicates that an impairment in the way certain proteins
fold and organize
in the body could be a fundamental cause of many autoimmune diseases.
Our scienctists have identified
novel enzymes which are the probable causes of this impairment, and we
have begun preclinical studies
targeting these enzymes. Unlike other approaches
that target the autoimmune response, this therapeutic approach targets
the source of auto-antigenicity, and therefore, we believe, the cause
of autoimmune disease.