The basal lamina of the glomerulus of the kidney is the target of the autoimmune disease Goodpasture sydrome. BioStratum scientists have determined the structure of
the autoantigenic site in this disease. A careful analysis
of the structure and function of this autoantigenic site has led to an understanding of what causes the body's proteins to become autoantigenic. This research indicates that an impairment in the way certain proteins fold and organize
in the body could be a fundamental cause of many autoimmune diseases. Our scienctists have identified
novel enzymes which are the probable causes of this impairment, and we have begun preclinical studies
targeting these enzymes. Unlike other approaches
that target the autoimmune response, this therapeutic approach targets the source of auto-antigenicity, and therefore, we believe, the cause of autoimmune disease.